Chin. J. Org. Chem. ›› 1989, Vol. 9 ›› Issue (5): 448-450. Previous Articles     Next Articles

17-次乙二氧基-3-甲氧基-雌甾-2,5(10)-二烯-11β-醇用硅胶支持的草酸试剂选择性水解

夏鹏;张志刚;袁盛耀   

  1. 上海医科大学药学院有机化学教研室
  • 发布日期:1989-10-25

The selective hydrolysis of 3-methoxy-estra-2,5(10)-diene-11β-ol with an oxalic acid reagent supported on silica gel

XIA PENG;ZHANG ZHIGANG;YUAN SHENGYAO   

  • Published:1989-10-25

Using oxalic acid reagent supported on silica gel 17-cyclic ethylenedioxo-3-methoxyestra-2,5(10)-dien-11b-ol (I) was converted into corresponding 3-one derivative II without migration of 5(10)-alkene bond and hydrolysis of 17-cyclic acetal group. This selective hydrolysis was carried out in mild condition and easily to be controlled. The product can be isolated conveniently with 66.7% yield. This new method is obviously superior to the reported procedures. The product from reaction of I with 70% acetic acid or oxalic acid/methanol is a complicated mixture and difficult to be purified.

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