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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 538-541. Previous Articles Next Articles
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王刚,张智勇*,未本美,张开诚,戴志群
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WANG Gang,ZHANG Zhi-Yong*,ZHANG Kai-ChengWEI Ben-Mei,DAI Zhi-Qun
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4-Alkylbiphenyls are important intermediates for synthesis of liquid crystals. In this paper the cross-coupling reaction of alkyl bromides with the Grignard reagent of p-bromobiphenyl provided a series of 4-alkylbiphenyl class compounds by using cupric chloride as the catalyst for C—C bond formation in yields of about 91%. The structures of these compounds were identified by elemental analysis, IR, 1H NMR and MS spectra. This synthesis has higher yields, is more environmental-friendly, and costs less than comparable traditional ways.
Key words: Grignard reagent cross-coupling reaction, cupric chloride catalyst, 4-alkylbiphenyl, liquid crystal intermediate
WANG Gang,ZHANG Zhi-Yong*,ZHANG Kai-ChengWEI Ben-Mei,DAI Zhi-Qun. Synthesis of 4-Alkylbiphenyls via Cross-Coupling Reaction Catalyzed by Cupric Chloride[J]. Chin. J. Org. Chem., 2008, 28(03): 538-541.
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