Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 538-541. Previous Articles     Next Articles

Reports

氯化铜催化偶联合成4-烷基联苯

王刚,张智勇*,未本美,张开诚,戴志群   

  1. (武汉工业学院化学与环境工程系 武汉 430023)
  • 收稿日期:2007-08-23 修回日期:2007-09-14 发布日期:2008-03-18
  • 通讯作者: 张智勇

Synthesis of 4-Alkylbiphenyls via Cross-Coupling Reaction Catalyzed by Cupric Chloride

WANG Gang,ZHANG Zhi-Yong*,ZHANG Kai-Cheng
WEI Ben-Mei,DAI Zhi-Qun   

  1. (Department of Chemical and Enviromental Engineering, Wuhan Polytechnic University, Wuhan 430023)
  • Received:2007-08-23 Revised:2007-09-14 Published:2008-03-18
  • Contact: ZHANG Zhi-Yong

4-Alkylbiphenyls are important intermediates for synthesis of liquid crystals. In this paper the cross-coupling reaction of alkyl bromides with the Grignard reagent of p-bromobiphenyl provided a series of 4-alkylbiphenyl class compounds by using cupric chloride as the catalyst for C—C bond formation in yields of about 91%. The structures of these compounds were identified by elemental analysis, IR, 1H NMR and MS spectra. This synthesis has higher yields, is more environmental-friendly, and costs less than comparable traditional ways.

Key words: Grignard reagent cross-coupling reaction, cupric chloride catalyst, 4-alkylbiphenyl, liquid crystal intermediate