NMR and chemical structure of a new saponin from Jiu  Jiujlong (Ardisea pusilla)

Chin. J. Org. Chem. ›› 2000, Vol. 20 ›› Issue (3): 361-366. Previous Articles Next Articles

四川九节龙中新四糖三萜皂苷结构和核磁共振研究

缪振春;冯锐;周永新;李光玉;张清华

军事医学科学院毒物药物研究所.北京(100Act);国家生物医学分析中心;华西医科大学药学院.成都(610044)

发布日期:2000-06-25

NMR and chemical structure of a new saponin from Jiu Jiujlong (Ardisea pusilla)

Miao Zhenchun;Feng Rui;Zhou Yongxin;Li Guangyu;Zhang Qinghua

Institute of Pharmacology and toxicology Academy of Military Med. Beijing(100Act);W China Univ Med Sci, Sch Pharm.Chengdu(610044)

Published:2000-06-25

Abstract

A new triterpenoid saponin has been isolated from Ardisea pusilla A. D C, which possesses improved immunological and antitumor activity. Its structure is deduced as 3-O-[α-L-(rhamno-pyranosyl-(1→3)-β -D- lucopyranosyl-(1→3)][β-D-glucopyranosyl(1→2)]-α -L- arabinopyranosyl cyclamiretin A. The results obtained show that the chemical structure of oligosaccharide chains of the saponin could be elucidated by using the techniques of 1D-SEMDY and NOE difference spectroscopy in rotating frame, without recourse to chemical degration or modification. Complete assignments of severely overlapping proton resonances of the sugar residues were achieved. The sites of glycosylation and the sequence of sugars in the glycoside can be determined unambiguously.

Key words: SICUAN, ARDISIA, TRADITIONAL CHINESE MEDICINAL HERBS, NUCLEAR MAGNETIC RESONANCE

CLC Number:

O621

Cite this article

Miao Zhenchun;Feng Rui;Zhou Yongxin;Li Guangyu;Zhang Qinghua. NMR and chemical structure of a new saponin from Jiu Jiujlong (Ardisea pusilla)[J]. Chin. J. Org. Chem., 2000, 20(3): 361-366.

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四川九节龙中新四糖三萜皂苷结构和核磁共振研究

NMR and chemical structure of a new saponin from Jiu Jiujlong (Ardisea pusilla)

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