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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (9): 1306-1308. Previous Articles Next Articles
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丁益萍，丁一，沈宗旋，李斌，张雅文*
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DING Yi-Ping,DING Yi,SHEN Zong-Xuan,LI Bin,ZHANG Ya-Wen*
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Chiral amino alcohol 1 was prepared from L-proline conveniently. In poly(ethyleneglycol) (PEG)(400), this chiral amino alcohol (30 mol%) catalyzes asymmetric Baylis-Hillman reaction effectively. High yields (up to 95.4%) and modest selectivities (up to 54.3% ee) were achieved. The chiral amino alcohol-PEG(400) catalytic system could be easily recovered and reused in the next run. No significant changes in the reaction yields and selectivities were found in the first three runs.
Key words: chiral animo alcohol, recycling, PEG(400), asymmetric Baylis-Hillman reaction
DING Yi-Ping,DING Yi,SHEN Zong-Xuan,LI Bin,ZHANG Ya-Wen*. Asymmetric Baylis-Hillman Reaction in Poly(ethyleneglycol)(400)[J]. Chin. J. Org. Chem., 2006, 26(9): 1306-1308.
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