Chin. J. Org. Chem. ›› 2000, Vol. 20 ›› Issue (5): 773-777. Previous Articles     Next Articles

苯酞类化合物重排反应的研究------3-位烷基取代苯 酞的重排反应

徐柏玲;庞素华;郭宗儒;梁晓天   

  1. 中国医学科学院;中国协和医科大学药物研究所
  • 发布日期:2000-10-25

Study on the rearrangement reaction of phthalides----the rearrangement reaction of 3-alkylphthalides

Xu Bailing;Pang Suhua;Guo Zongru;Liang Xiaotian   

  • Published:2000-10-25

A rearrangement reaction of 3-butylphthalide to 1-methyl-5-carboxyl- tetrahydro naphthalene under the catalysis of AlCl~3 by hydride transfer was observed. With different side chains at the 3-position of the phthalide, either hydride transfer or alkyl transfer would take place in the rearrangement reaction depending upon the stability of resulting carbonium species, leading to different products.

Key words: MIGRATION MECHANISM, SPECTROMETRIC ANALYSIS, ALUMINIUM CHLORIDE, REARRANGEMENT REACTION

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