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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (05): 671-675. Previous Articles     Next Articles

Original Articles

多氟烷基取代的环丙烷衍生物的合成

吴范宏*,1，顾松1，黄维垣2   

  1. (1华东理工大学化学与制药学院 上海 200237)
    (2中国科学院上海有机化学研究所有机氟化学开放实验室 上海 200032)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2006-04-28
  • 通讯作者: 吴范宏*

Synthesis of Polyfluoroalkyl Substituted Cyclopropane Derivatives

WU Fan-Hong*,1,GU Song1,HUANG Wei-Yuan2   

  1. (1 College of Chemistry and Pharmaceutics, East China University of Science and Technology, Shanghai 200237)
    (2 Open Laboratory of Organic Fluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:1900-01-01 Revised:1900-01-01 Published:2006-04-28
  • Contact: WU Fan-Hong

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A new convenient synthesis of a series of polyfluoroalkyl substituted cyclopropane derivatives was achieved by the reaction of polyfluoroalkyl iodides with diethyl allylmalonate in the presence of sodium dithionite in 45%～55% yields. The reaction of ethyl allylacetoacetate with polyfluoroalkyl iodides under similar conditions gave the corresponding adducts, which were sequentially treated with base to the cyclization products.

Key words: cyclopropane derivative, sodium dithionite, polyfluoroalkyl iodide