Synthesis and Herbicidal Evaluation of Novel 3-(Hydroxymethylene)pyrrolidine-2,4-dione

Abstract

In order to further study the structure-activity relationships (SAR) of the title compounds and find new kinds of herbicides, nineteen new compounds were prepared by reaction of nineteen ketoacid esters with amio-acid esters. All of them have been confirmed by ¹H NMR and elemental analysis. The preliminary bioassay results indicated that their inhibiting rates were higher than sulcotrione. In comparison with the re-ported compounds with excellent herbicidal activity, their inhibiting rates against B. campestrisroot were elevated significantely while their inhibiting rates against E. crus-galli were not improved.

Key words: pyrrolidine, p-hydroxyphenypyruvate dioxydenase, herbicide

Cite this article

ZHU You-Quan,SI Xue-Kai,ZOU Xiao-Mao*,LIU Bin,YANG Hua-Zheng*. Synthesis and Herbicidal Evaluation of Novel 3-(Hydroxymethylene)pyrrolidine-2,4-dione[J]. Chin. J. Org. Chem., 2007, 27(03): 385-390.

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新型3-羟亚甲基吡咯烷-2,4-二酮衍生物的合成与除草活性研究