Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (06): 1040-1043. Previous Articles     Next Articles

Original Articles

meso-去甲二氢愈创木酸和Machilin A的合成

夏亚穆*,a,王琦a,丁一宁a,杨丰科a,曹小平b   

  1. (a青岛科技大学化工学院 青岛 266042)
    (b兰州大学化学化工学院 兰州 730000)
  • 收稿日期:2007-09-22 修回日期:2007-11-29 发布日期:2008-06-26
  • 通讯作者: 夏亚穆

Synthesis of meso-Nordihydroguaiaretic Acid and Machilin A

XIA Ya-Mu*,a, WANG Qi a, DIN Yi-Ninga, YANG Feng-Kea, CAO Xiao-Pingb   

  1. (a College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042)
    (b College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000)
  • Received:2007-09-22 Revised:2007-11-29 Published:2008-06-26
  • Contact: XIA Ya-Mu

A novel synthetic route to natural nordihydroguaiaretic acid and Machilin A is described. This method involves two Stobbe condensations to give the skeleton of lignan, then fellowed by transformation of functional groups to obtain target compounds. The method operation is convenient and practical.

Key words: Machilin A, Stobbe condensation, nordihydroguaiaretic acid