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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1437-1441. Previous Articles Next Articles
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郭振楚*,1,熊兴泉1,2
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GUO Zhen-Chu*,1,XIONG Xing-Quan1,2
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By using trichloroacetyl, trichloroacetimidate group and ethylthio as the protection system and through five steps, protected β-(1→3)-2-amino-2-deoxydiglucose 7 was synthesized from β-tetra-O-acetyl-glucosylamine hydrochloride (1). β-(1→3)-2-amino-2-deoxydiglucose acceptor 8 was also produced by two steps. Finally protected β-(1→3)-2-amino-2-deoxytriglucose 10 was obtained through eight steps with the tolal yield of 27%. These compounds are all new ones. Using this protection system, amino- oligosaccharides can be selectively synthesized with high yield.
Key words: glucosylamine hydrochloride, trichloroacetyl chloride, trichloroacetimidate, ethanethiol, 2-amino-2-deoxyl-triglucose
GUO Zhen-Chu*,1,XIONG Xing-Quan1,2. Synthesis of Protected 2-Amino-2-deoxytriglucose[J]. Chin. J. Org. Chem., 2005, 25(11): 1437-1441.
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