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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 738-740. Previous Articles     Next Articles

Reports

三苯甲基醚直接转化成丙酮化合物的反应

王瑾*,1，钟振声1，刘爱骅2   

  1. (1华南理工大学应用化学系 广州 510641)
    (2产业技术综合研究所 筑波 305-0051 日本)
  • 收稿日期:2004-08-05 修回日期:2004-12-27 发布日期:2005-05-30
  • 通讯作者: 王瑾

One-step Transformation of the Trityl Ether to the Acetonide

WANG Jin*1,ZHONG Zhen-Sheng1, LIU Ai-Hua2   

  1. (1 Department of Applied Chemistry, South China University of Technology, Guangzhou 510641)
    (2 National Institute of Advanced Industrial Science and Technology, Tsukuba 305-0051, Japan)
  • Received:2004-08-05 Revised:2004-12-27 Published:2005-05-30
  • Contact: WANG Jin

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This paper details an efficient method for a one-step transformation of the trityl ether to the acetonide. Treatment of trityl ether with a mixture of trifluoroacetic acid, 2,2-dimethoxy propane and camphorsulfonic acid as catalyst in dichloromethane through detritylation followed by acetonization gave the acetonide in high yield. This method was highly applicable to use with detritylation of the alcohols bearing acid-hydrolyzable functionalities.

Key words: trityl ether, acetonide, detritylation