Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics

doi:10.6023/cjoc201207006

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1568-1576.DOI: 10.6023/cjoc201207006 Previous Articles Next Articles

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抗肿瘤活性四氢异喹啉类抗生素的生物合成研究进展

唐满成, 唐功利

中国科学院上海有机化学研究所生命有机化学国家重点实验室上海 200032

收稿日期:2012-07-05 修回日期:2012-07-29 发布日期:2012-07-18
通讯作者: 唐功利 E-mail:gltang@sioc.ac.cn
基金资助:
国家自然科学基金(Nos.81102337, 20832009)和国家重点基础研究发展计划(No.2012CB721100)资助项目

Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics

Tang Mancheng, Tang Gongli

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2012-07-05 Revised:2012-07-29 Published:2012-07-18
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.81102337, 20832009) and the National Basic Research Program of China (No.2012CB721100)

Due to the unique chemical structures and antitumor activity, tetrahydroisoquinoline alkaloids have long been the focus of widespread concern of chemists and biologists. In particular, with the continuous progress of new biotechnology, the biosynthetic studies of this type of antibiotics have made rapid development over the past decade. In this paper, the main achievements of these studies are reviewed, including the biosynthesis of safracin B, saframycin A, naphthyridinomycin, quinocarcin, and ecteinascidin 743, especially the biosynthetic studies of their core tetrahydroisoquinoline ring structure, such as the core structure precursor resources, the biosynthetic pathway of these precursors, and the formation mechanism of the tetrahydroisoquinoline ring.

Key words: tetrahydroisoquinoline alkaloid, tetrahydroisoquinoline ring, precursor resource, biosynthetic pathway, Pictet-Spengler reaction

Cite this article

Tang Mancheng, Tang Gongli. Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics[J]. Chin. J. Org. Chem., 2012, 32(9): 1568-1576.

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抗肿瘤活性四氢异喹啉类抗生素的生物合成研究进展

Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics

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