Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

doi:10.6023/cjoc201212020

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (05): 1080-1087.DOI: 10.6023/cjoc201212020 Previous Articles Next Articles

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聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

马晓晔^a, 施丽君^b,c, 周涓^b, 朱君^b, 钟建^b, 魏锐利^a

a 第二军医大学附属长征医院眼科上海 200003;
b 纳米技术及应用国家工程研究中心上海 200241;
c 上海交通大学材料学院上海 200240

收稿日期:2012-12-13 修回日期:2012-12-20 发布日期:2013-01-04
通讯作者: 魏锐利,ruiliwei@gmail.com;周涓,xmcjuan@gmail.com E-mail:ruiliwei@gmail.com;xmcjuan@gmail.com
基金资助:
全军医学科技“十二五”科研(面上项目, No. CWS11J131)和上海市自然科学基金(No. 11ZR1425200)资助项目.

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

Ma Xiaoye^a, Shi Lijun^b,c, Zhou Juan^b, Zhu Jun^b, Zhong Jian^b, Wei Ruili^a

a Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003;
b National Engineering Research Center for Nanotechnology, Shanghai 200241;
c College of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240

Received:2012-12-13 Revised:2012-12-20 Published:2013-01-04
Supported by:
Project supported by the Army Medical Technology “12th Five-Year Plan” Scientific Research Projects of China (Surface Project, CWS11J131) and the Natural Science Foundation of Shanghai (11ZR1425200).

A self-inflating hydrogel based on silk fibroin (SF) and poly(sodium acrylate) (PAAS) was synthesized by the free radical copolymerization. Furthermore, its potential as a tissue implant with minimally invasive treatment was investigated. The effects of the weight ratio of SF to AA (acrylic acid) on the structure, swelling properties and mechanical properties of the PAAS-SF semi-IPN hydrogels were investigated. In addition, the loading and release of amoxicillin of the PAAS-SF semi-IPN hydrogels were studied. With increasing SF content in the hydrogels, the swelling ratio and the rate of drug release increased, while the compressive strength decreased. It was observed that (83.4±0.9)% of the loaded drug was released within 120 h for the PAAS-SF20 semi-IPN hydrogels. The results revealed that the self-inflating PAAS-SF semi-IPN hydrogels with high swelling ratio and good drug releasing capabilities may have potential in the drug delivery or other implantable materials.

Key words: self-inflating, silk fibroin, poly(sodium acrylate), swelling ratio, drug release

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Ma Xiaoye, Shi Lijun, Zhou Juan, Zhu Jun, Zhong Jian, Wei Ruili. Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties[J]. Chin. J. Org. Chem., 2013, 33(05): 1080-1087.

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聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

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