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Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1333-1336.DOI: 10.6023/cjoc201305025 Previous Articles     Next Articles

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海南暗罗根中一个新的克罗烷型二萜

李小宝, 宋小平, 陈光英, 韩长日, 陈文豪, 郑彩娟, 宋鑫明   

  1. 海南师范大学化学与化工学院 热带药用植物化学教育部重点实验室 海口 571158
  • 收稿日期:2013-05-15 修回日期:2013-05-28 发布日期:2013-06-04
  • 通讯作者: 宋小平 E-mail:sxp628@126.com
  • 基金资助:

    国家自然科学基金(Nos.81160391, 21166009, 21162009)和科技部973计划前期研究专项(No.2011CB512010)资助项目.

A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

Li Xiaobao, Song Xiaoping, Chen Guangying, Han Changri, Chen Wenhao, Zheng Caijuan, Song Xinming   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2013-05-15 Revised:2013-05-28 Published:2013-06-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81160391, 21166009 and 21162009), the 973 Research Program of the Ministry of Science and Technology of China (No.2011CB512010).

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Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy (TLC).Their structures were elucidated as polyalimide A (1),kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4), 3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), and solidagonal acid methyl ester (8).Compound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were isolated for the first time from this plant material.Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

Key words: Polyalthia, Polyalthia laui Merr., polyalimide A