Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (3): 475-484.DOI: 10.6023/cjoc201310033 Previous Articles     Next Articles

Reviews

海洋抗肿瘤环酯肽Apratoxin A研究进展

张伟, 刘国运, 尹溽纹, 李英霞   

  1. 复旦大学药学院 上海 201203
  • 收稿日期:2013-10-21 修回日期:2013-12-04 发布日期:2013-12-06
  • 通讯作者: 李英霞 E-mail:liyx417@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(No. 81001392,81172975);复旦大学青年教师科研能力提升项目和国家高技术研究发展计划(863计划,No. 2013AA092903)资助项目.

Research Progress of Apratoxin A:A Marine Cyclicdepsipeptide with Significant Anti-cancer Activity

Zhang Wei, Liu Guoyun, Yin Ruwen, Li Yingxia   

  1. School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2013-10-21 Revised:2013-12-04 Published:2013-12-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81001392, 81172975), the Project to Enhance the Research Ability of Young Teachers (Fudan University), and the National High Technology Research and Development Program of China (863 Program, No. 2013AA092903).

Apratoxin A, a marine natural cyclicdepsipeptide bearing novel and complex structure, showed significant antiproliferative activity against several cancer cell lines. A brief introduction on the research progress of this natural product including total synthesis, structure-activity relationship, pharmacological studies, and biosynthetic pathway was summarized.

Key words: apratoxin A, marine bioactive peptide, anti-cancer