Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (5): 886-892.DOI: 10.6023/cjoc201402006 Previous Articles     Next Articles

ARTICLE

AgOAc为氧化剂制备活性白藜芦醇二聚体衍生物

张元a,b, 王先分a, 侯琦a, 林明宝a, 姚春所a, 石建功a   

  1. a 中国医学科学院北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验室 北京 100050;
    b 河北师范大学化学与材料科学学院 石家庄 050024
  • 收稿日期:2014-02-05 修回日期:2014-03-19 发布日期:2014-04-01
  • 通讯作者: 姚春所,石建功 E-mail:yaocs@imm.ac.cn;shijg@imm.ac.cn

Preparation of Active Resveratrol Dimeric Derivatives by Oxidative Coupling Reaction Using AgOAc as Oxidant

Zhang Yuana,b, Wang Xianfena, Hou Qia, Lin Mingbaoa, Yao Chunsuoa, Shi Jiangonga   

  1. a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050;
    b College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050024
  • Received:2014-02-05 Revised:2014-03-19 Published:2014-04-01

Oxidative coupling reaction of resveratrol in methanol using silver acetate as oxidant gave seven resveratrol dimeric derivatives 1~7. Their structures and relative configurations were determined on the basis of spectral analysis, and their formation mechanisms were discussed, respectively. Among them, compounds 3, 4 and 5 were determined as new stilbene dimers, and compounds 6 and 7 were synthesized as natural compounds for the first time. All the compounds were evaluated for anti-inflammatory activities.

Key words: silver acetate, oxidative coupling reaction, resveratrol dimeric derivatives, anti-inflammatory acivities