Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one

doi:10.6023/cjoc201512008

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1368-1374.DOI: 10.6023/cjoc201512008 Previous Articles Next Articles

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超声辐射法合成2-硫亚基喹唑啉-4(1H)-酮类化合物及其抗植物病原菌活性研究

张金, 程佩, 马养民, 刘佳, 苗智, 范超

陕西科技大学化学与化工学院教育部轻化工助剂化学与技术重点实验室西安 710021

收稿日期:2015-12-05 修回日期:2016-01-28 发布日期:2016-02-18
通讯作者: 马养民 E-mail:mym63@sina.com
基金资助:
陕西省科技厅自然科学基础研究计划(No.2014JQ2064)、陕西科技大学博士科研启动基金(No.BJ12-26)资助项目.

Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one

Zhang Jin, Cheng Pei, Ma Yangmin, Liu Jia, Miao Zhi, Fan Chao

Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021

Received:2015-12-05 Revised:2016-01-28 Published:2016-02-18
Supported by:
Project supported by the Natural Science Basic Research Plan in Shaanxi Province (No. 2014JQ2064) and the Foundation for Young Scholars of Shaanxi University of Science & Technology (No. BJ12-26).

1. Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one.PDF(2428KB)

Abstract

In order to develop new potent anti-phytopathogenic fungi drugs, a series of 2-sulfanylidene-2,3-dihydroquinazo- line-4(1H)-ones were synthesized under ultrasonic irradiation. Structures of the compounds were characterized by IR, ¹H NMR, ¹³C NMR and MS. All compounds were investigated for anti-phytopathogenic fungi activity via the method of minimum inhibitory concentrations. The majority of compounds exhibited a good inhibitory activity to Alternaria brassicae and Colletotrichum gloeosporioides. The minimum inhibitory concentrations of compounds 3a, 3b, 3g and 3h were 16 μg/mL, which showed significant inhibitory activity to Alternaria brassicae compared with that of the positive control drug ketoconazole.

Key words: ultrasonic irradiation, 2-sulfanylidene-2,3-dihydroquinazoline-4(1H)-one, anti-phytopathogenic fungi activity, minimum inhibitory concentrations

Cite this article

Zhang Jin, Cheng Pei, Ma Yangmin, Liu Jia, Miao Zhi, Fan Chao. Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one[J]. Chin. J. Org. Chem., 2016, 36(6): 1368-1374.

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超声辐射法合成2-硫亚基喹唑啉-4(1H)-酮类化合物及其抗植物病原菌活性研究

Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one

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