In the Presence of FeCl3 Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers

doi:10.6023/cjoc201610046

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 920-924.DOI: 10.6023/cjoc201610046 Previous Articles Next Articles

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FeCl₃作用下烯基醇的碘代环醚化反应:一种合成碘代环醚的简便方法

范卫永^a, 余磊^b, 彭湘君^b, 刘良先^a

a. 赣南师范大学化学化工学院赣州 341000;
b. 赣南医学院药学院赣州 341000

收稿日期:2016-10-31 修回日期:2016-12-23 发布日期:2017-01-10
通讯作者: 彭湘君, 刘良先 E-mail:pengxiangjun99@126.com;lxliu@xmu.edu.cn

In the Presence of FeCl₃ Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers

Fan Weiyong^a, Yu Lei^b, Peng Xiangjun^b, Liu Liangxian^a

a. Department of Chemistry and Biology, Gannan Teachers' College, Ganzhou 341000;
b. School of Pharmaceutical Science, Gannan Medical University, Ganzhou 341000

Received:2016-10-31 Revised:2016-12-23 Published:2017-01-10
Contact: 10.6023/cjoc201610046 E-mail:pengxiangjun99@126.com;lxliu@xmu.edu.cn

1. In the Presence of FeCl₃ Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers.PDF(676KB)

Abstract

In the presence of FeCl₃ reaction of alkenols with iodine resulted in intramolecular addition of hydroxyl to alkenol to produce a wide range of iodocyclic ethers in good to excellent yields under mild reaction conditions. The advantages of our procedure include a decreased amount of iodine as well as short reaction times. The broad scope, mild reaction conditions, and experimental ease of this transformation have made it a valuable alternative to current available methods for the preparation of iodocyclic ethers.

Key words: intramolecular iodoetherification, iron trichloride, alkenol

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Fan Weiyong, Yu Lei, Peng Xiangjun, Liu Liangxian. In the Presence of FeCl₃ Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers[J]. Chin. J. Org. Chem., 2017, 37(4): 920-924.

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FeCl₃作用下烯基醇的碘代环醚化反应:一种合成碘代环醚的简便方法

In the Presence of FeCl₃ Reaction of Alknols with Iodine: A Convenient Synthetic Route to Iodocyclic Ethers

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FeCl3作用下烯基醇的碘代环醚化反应:一种合成碘代环醚的简便方法