Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines

doi:10.6023/cjoc201704049

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2678-2684.DOI: 10.6023/cjoc201704049 Previous Articles Next Articles

ARTICLE

镍催化的8-氨基喹啉C—H键卤化反应合成C(5)和C(7)双卤代喹啉

郝文燕, 王昱赟, 杨国敏, 刘云云

江西师范大学化学化工学院南昌 330022

收稿日期:2017-04-28 修回日期:2017-06-23 发布日期:2017-07-04
通讯作者: 郝文燕, 刘云云 E-mail:wenyanhao@jxnu.edu.cn;chemliuyunyun@jxnu.edu.cn
基金资助:
国家自然科学基金（Nos.21562024，21762023）及江西省教育厅（No.GJJ160285）资助项目.

Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines

Hao Wenyan, Wang Yuyun, Yang Guomin, Liu Yunyun

College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022

Received:2017-04-28 Revised:2017-06-23 Published:2017-07-04
Contact: 10.6023/cjoc201704049 E-mail:wenyanhao@jxnu.edu.cn;chemliuyunyun@jxnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.21562024,21762023) and the Scientific Research Fund of Jiangxi Provincial Education Department (No.GJJ160285).

1. Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines.PDF(2080KB)

Abstract

A simple and efficient nickel-catalyzed oxidative halogenation (Cl, Br) of C(5) and C(7) C-H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and easy availability nickel as catalyst and oxygen as oxidant. The reactions have good functional groups compatibility, giving highly selective C(5) and C(7) di-halogenated products in good to excellent yields.

Key words: Nickel-catalyze, C—H halogenation, N-bromo-succinimide, 8-aminoquinolines, dihalogenated quinoline

Cite this article

Hao Wenyan, Wang Yuyun, Yang Guomin, Liu Yunyun. Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines[J]. Chin. J. Org. Chem., 2017, 37(10): 2678-2684.

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镍催化的8-氨基喹啉C—H键卤化反应合成C(5)和C(7)双卤代喹啉

Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines

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