Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2985-2992.DOI: 10.6023/cjoc201703050 Previous Articles     Next Articles

Articles

铟粉促进下“一锅法”合成α-亚甲基-γ-三氟甲基-γ-丁内酰胺化合物

李军, 黄丹凤, 张怀远, 张兴虎, 王娟娟, 王克虎, 苏瀛鹏, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2017-03-30 修回日期:2017-07-03 发布日期:2017-07-14
  • 通讯作者: 黄丹凤, 胡雨来 E-mail:huangdf@nwnu.edu.cn;huyl@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21662030,21462037)资助项目.

Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction

Li Jun, Huang Danfeng, Zhang Huaiyuan, Zhang Xinghu Wang Juanjuan, Wang Ke-Hu, Su Yingpeng, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2017-03-30 Revised:2017-07-03 Published:2017-07-14
  • Contact: 10.6023/cjoc201703050 E-mail:huangdf@nwnu.edu.cn;huyl@nwnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21462037).

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and ethyl 2-(bromomethyl)acrylate promoted by indium powder has been investigated and a series of α-methylene-γ-trifluoromethyl-γ-lactams were obtained with high yieds. The features of this process include readily available starting materials as trifluoromethyl source, mild conditions and easy operation. The reaction provides a new method for the snythesis of trifluoromethylated α-methylene-γ-lactams.

Key words: one-pot, indium powder, trifluoroacetaldehyde methyl hemiacetal, trifluoroketone, 2-(bromomethyl) acrylate, arylacylhydrazine, α-methylene-γ-trifluoromethyl-γ-lactams