Green Synthesis of Indanone Fused Pyrrole Compounds

doi:10.6023/cjoc201706002

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3204-3212.DOI: 10.6023/cjoc201706002 Previous Articles Next Articles

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茚酮并吡咯类化合物的绿色合成

罗大云, 胡兴梅, 资全兴, 林军, 严胜骄

云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091

收稿日期:2017-06-01 修回日期:2017-07-05 发布日期:2017-08-18
通讯作者: 林军, 严胜骄 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
基金资助:
国家自然科学基金（Nos.21362042，21662042，U1202221，21262042），云南省自然科学基金（No.2017FA003）、云南省后备人才（No.2012HB001）、云南大学东陆学者和云南大学青年英才计划资助项目.

Green Synthesis of Indanone Fused Pyrrole Compounds

Luo Dayun, Hu Xingmei, Zi Quanxing, Lin Jun, Yan Shengjiao

Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091

Received:2017-06-01 Revised:2017-07-05 Published:2017-08-18
Contact: 10.6023/cjoc201706002 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University.

1. Green Synthesis of Indanone Fused Pyrrole Compounds.PDF(4008KB)

Abstract

green synthetic method was constructed for the synthesis of indanone fused pyrrolone compounds, which based on the catalyst-free reaction of N-alkyl-1-methylthio-2-nitroethenamine (1) with ninhydrin hydrate (2) in ethanol at reflux. As a result, a series of indanone fused pyrrolones have been synthesized with 91%~98% yields by this one-step reaction. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.

Key words: N-alkyl-1-methylthio-2-nitroethenamine, ninhydrin, indanone, pyrrole, green synthesis

Cite this article

Luo Dayun, Hu Xingmei, Zi Quanxing, Lin Jun, Yan Shengjiao. Green Synthesis of Indanone Fused Pyrrole Compounds[J]. Chin. J. Org. Chem., 2017, 37(12): 3204-3212.

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茚酮并吡咯类化合物的绿色合成

Green Synthesis of Indanone Fused Pyrrole Compounds

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