Recent Advances in Closed-Loop and Smart Insulin Delivery Systems

doi:10.6023/cjoc201708065

Abstract

Insulin is a commonly prescribed drug for the treatment of type I and type Ⅱ diabetes. As for the efficiency in controlling blood glucose level, insulin therapy is one of the most effective treatments for diabetes. The current administration route of insulin is mainly through subcutaneous injection, which leads to many undesirable side effects such as pain, local tissue necrosis or infection, and nerve damage. Recently, various closed-loop and smart insulin delivery systems have been developed based on the emerging nanotechnologies. Recent progress in the construction of closed-loop and smart insulin delivery system, which mainly focuses on the response mechanism, different strategies for fabricating the carrier matrix, and the regulation principle of the smart insulin release is described. Advantages and drawbacks of the current insulin delivery systems are also discussed, along with the opportunities and challenges in future.

Key words: diabetes, insulin, glucose-response, closed-loop delivery system, smart drug release

Cite this article

Li Zhenyi, Hu Xiaoyu, Jiang Juli, Zhang Dongmei, Xiao Shoujun, Lin Chen, Wang Leyong. Recent Advances in Closed-Loop and Smart Insulin Delivery Systems[J]. Chin. J. Org. Chem., 2018, 38(1): 29-39.

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