Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2625-2632.DOI: 10.6023/cjoc201804025 Previous Articles     Next Articles

Reviews

阿片类药物研发近期热点

潘陈玲a,b, 孟浩c,d, 汪亮亮b, 沈悦海a,b, 左之利b, 王冠林a, 张宽仁a   

  1. a 昆明理工大学 生命科学与技术学院 昆明 650500;
    b 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室 昆明 650000;
    c 北京市科学技术研究院 北京市计算中心 北京 100094;
    d 北京北科德源生物医药科技有限公司 北京 100094
  • 收稿日期:2018-04-13 修回日期:2018-05-17 发布日期:2018-06-01
  • 通讯作者: 沈悦海,E-mail:yuehaishen@kmust.edu.cn E-mail:yuehaishen@kmust.edu.cn
  • 基金资助:

    国家自然科学基金(No.21772207)和中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室开放课题(No.P2015-KF04)资助项目.

Recent Topics in Research and Development of Opioid Drugs

Pan Chenlinga,b, Meng Haoc,d, Wang Liangliangb, Shen Yuehaia,b, Zuo Zhilib, Wang Guanlina, Chang Kwen-jena   

  1. a Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500;
    b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201;
    c Beijing Computing Center, Beijing Academy of Science and Technology, Beijing 100094;
    d Beijing Beike Deyuan Bio-Pharm Technology Co., Ltd., Beijing 100094
  • Received:2018-04-13 Revised:2018-05-17 Published:2018-06-01
  • Contact: 10.6023/cjoc201804025 E-mail:yuehaishen@kmust.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21772207) and the State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2015-KF04).

Opioid drugs are widely used in clinical practice, but they are also notorious for their respiratory depression and addictive side effects. Therefore, tremendous efforts have been paid to the research and development of opioid drugs. Recent progresses in related research fields provide important clues for developing opioid drugs with novel mechanisms. Recent reports on several topics in the study of small molecule opioid drugs are summarized.

Key words: opioid drug, opioid receptor, opioid side effects, drug research