Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway

doi:10.6023/cjoc201806003

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 328-338.DOI: 10.6023/cjoc201806003 Previous Articles Next Articles

REVIEW

环二肽合酶生物合成途径研究进展

张京星^a, 姚婷婷^a, 刘晶^a, 李花月^a,b, 李文利^a,b

a 中国海洋大学医药学院教育部海洋药物重点实验室青岛 266003;
b 青岛海洋科学与技术国家实验室海洋生物学与生物技术功能实验室青岛 266237

收稿日期:2018-06-01 修回日期:2018-09-10 发布日期:2018-09-18
通讯作者: 李文利 E-mail:liwenli@ouc.edu.cn
基金资助:
国家自然科学基金（Nos.31171201，81561148012，31570032）资助项目.

Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway

Zhang Jingxing^a, Yao Tingting^a, Liu Jing^a, Li Huayue^a,b, Li Wenli^a,b

a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003;
b Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237

Received:2018-06-01 Revised:2018-09-10 Published:2018-09-18
Contact: 10.6023/cjoc201806003 E-mail:liwenli@ouc.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 31171201, 81561148012, 31570032).

Diketopiperazines (DKPs) are derivatives of cyclodipeptides resulted from the condensation of two α-amino acids. The conformationally constrained six-membered ring makes DKP an attractive pharmacophore in medicinal chemistry, exhibiting a wide range of bioactivities. Recently, there has been increased interests in synthesizing DKPs and biosynthesis is an effective pathway to broaden their structural diversity. Different from non-ribosomal peptide synthetases (NRPSs)-dependent pathways, cyclodipeptide synthases (CDPSs) use aminoacyl-tRNAs (aa-tRNAs) as substrates and the resulting cyclodipeptides are further modified by associated tailoring enzymes to yield the final products. To date, six CDPS-dependent pathways for synthesizing DKPs compounds have been reported. A brief overview of recent progresses on CDPS-dependent DKPs biosynthetic pathway is provided.

Key words: diketopiperazines, non-ribosomal peptide synthetases, cyclodipeptide synthases, biosynthetic pathway

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Zhang Jingxing, Yao Tingting, Liu Jing, Li Huayue, Li Wenli. Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway[J]. Chin. J. Org. Chem., 2019, 39(2): 328-338.

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环二肽合酶生物合成途径研究进展

Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway

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