Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents

doi:10.6023/cjoc202005016

Abstract

In the past two decades, the development and application of bench-stable electrophilic difluoromethylating reagents have attracted considerable attention. Consequently, some progress in this area has been ongoing recently. Electrophilic difluoromethylating reagents play a very important role in the synthesis of fluorine-containing compounds, due to their capability of readily transferring difluoromethyl moiety (CF₂H) into wide range of nucleophiles, as well as being used as difluoromethyl radical(•CF₂H) precursorfor radical difluoromethylations. However, the electrophilic difluoromethylating reagents and application therein remain still underdeveloped in comparison with nucleophilic ones. The research advance in electrophilic difluoromethylating reagents in past two decades is reviewed.

Key words: electrophilic difluoromethylating reagent, electrophilic difluoromethylation reaction, radical difluoromethylation reaction, difluorocarbene

Cite this article

Qin Wenbing, Chen Jiayi, Xiong Wei, Liu Guokai. Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3177-3195.

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