Three-component one-pot synthesis of novel 1,5-benzodiazepine derivatives and their anti-BVDV activity

doi:10.6023/cjoc202004018

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“一锅”三组分合成新型1,5-苯并二氮杂卓类化合物与抗BVDV活性

韩超^a, 聂磊^a, 韩晓^b, 张岩^a, 孙克磊^a, 石磊^a, 崔光华^a, 孟伟^a

a 华北理工大学化学工程学院唐山 063210;
b 邯郸学院化学化工与材料学院邯郸 056005

收稿日期:2020-04-12 修回日期:2020-06-17 发布日期:2020-09-30
通讯作者: 韩超 E-mail:hanchao@ncst.edu.cn
基金资助:
河北省自然科学基金委，青年基金项目（No.B2017209119）、河北省教育厅，河北省高等学校科学技术研究项目（No.Z2017013）资助项目.

Three-component one-pot synthesis of novel 1,5-benzodiazepine derivatives and their anti-BVDV activity

Chao Han^a, Lei Nie^a, Xiao Han^b, Yan Zhang^a, Kelei Sun^a, Lei Shi^a, Guanghua Cui^a, Wei Meng^a

a College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063210, China;
b College of Chemical Engineering&Material, Handan University, Handan, 056005, China

Received:2020-04-12 Revised:2020-06-17 Published:2020-09-30
Supported by:
Project supported by the Natural Science Foundation of Hebei Province of China (No. B2017209119) and the education department of Hebei Province of China (No. Z2017013).

1. cjoc202004018.pdf(1995KB)

Abstract

The "one-pot" three-component reaction is established to synthesize 1,5-benzodiazepine derivatives containing pyrrolidinone. These reactions were carried out readily with p-toluenesulfonic acid (p-TSA) as the catalyst in good yields. Reaction conditions were mild, environmental friendly. The benzodiazepine derivatives displayed prominent anti-BVDV activity with excellent EC₅₀ values and no significant cytotoxicity. Our research could afford significative compounds for the research of anti-BVDV agents.

Key words: “one-pot” three-component reaction, 1,5-benzodiazepine derivatives, p-TSA, pyrrolidinone, anti-BVDV

Cite this article

Chao Han, Lei Nie, Xiao Han, Yan Zhang, Kelei Sun, Lei Shi, Guanghua Cui, Wei Meng. Three-component one-pot synthesis of novel 1,5-benzodiazepine derivatives and their anti-BVDV activity[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202004018.

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“一锅”三组分合成新型1,5-苯并二氮杂卓类化合物与抗BVDV活性

Three-component one-pot synthesis of novel 1,5-benzodiazepine derivatives and their anti-BVDV activity

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