Sesquiterpenes from Caragana Intermedia

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (7): 806-810. Previous Articles Next Articles

中间锦鸡儿中的倍半萜类化合物

孙智华, 张甦, 施蛟, 胡昌奇^*

复旦大学药学院天然药物化学教研室上海 200032

收稿日期:2004-04-28 修回日期:2004-05-07 接受日期:2004-05-18 发布日期:2022-09-20
通讯作者: ^*E-mail: changqihu@online.sh.cn; Fax: (021) 54237079.
基金资助:
国家自然科学基金(No. 30070085)资助项目

Sesquiterpenes from Caragana Intermedia

SUN, Zhi-Hua, ZHANG, Su, SHI, Jiao, HU, Chang-Qi^*

Department of Chemistry of Natural Products, School of Pharmacy, Fudan University, Shanghai 200032

Received:2004-04-28 Revised:2004-05-07 Accepted:2004-05-18 Published:2022-09-20

Abstract

Two novel sesquiterpenoids, eudesm-4(15)-ene-1β,8α-diol (1) and trans-octahydroindane-7β-isopropyl-4-methylene-9β-methyl-1β-ol (2), four known compounds, alloaromadendrane-3α,9α-diol (3), (+)-3α,9β-aromaden-dranediol (4), (+)-spathulenol (5) and (+)-lariciresinol (6), were isolated from an aerial partof Caragana intermedia. (+)-10α-Bromospathulenol (7) was prepared from compound 5. Compounds 1, 2, 3, 4, 5 and 7 showed anti-pyriculariaoryzae P-2b activity with MIC value of 38, 10, 25, 18, 9 and 35 μg/mL,respectively. The structures of these compounds were determined by spectral dataincluding 1D, 2D NMR, IR and HRMS spectra. Compound 4 was confirmed by X-ray crystallographic analysis.

Key words: Caragana intermedia, sesquiterpenes, indane, eudesmene

Cite this article

SUN, Zhi-Hua, ZHANG, Su, SHI, Jiao, HU, Chang-Qi. Sesquiterpenes from Caragana Intermedia[J]. Chinese Journal of Organic Chemistry, 2004, 24(7): 806-810.

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中间锦鸡儿中的倍半萜类化合物

Sesquiterpenes from Caragana Intermedia

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