Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (4): 1348-1356.DOI: 10.6023/cjoc202310019 Previous Articles     Next Articles

矮陀陀中一个新的脂肪酸苷类化合物

刘培源a,b, 韦玉璐b, 宋静茹b, 颜小捷b, 卢凤来b, 陈月圆b, 羊学荣b,*(), 李典鹏b,c,*()   

  1. a 桂林医学院药学院 广西桂林 541004
    b 广西壮族自治区中国科学院广西植物研究所 广西植物功能物质与资源持续利用重点实验室 广西桂林 541006
    c 广西中医药大学 中药壮瑶药创新药物教育部工程研究中心 广西南宁 530200
  • 收稿日期:2023-10-22 修回日期:2023-11-28 发布日期:2023-12-15
  • 基金资助:
    广西自然科学基金(2020GXNSFBA297055); 广西科技基础条件与人才计划(桂科AA21196009); 国家重点研发项目(2022YFD1600302); 国家自然科学基金(U20A2004); 广西科学院基础研究基金(CQZ-C-1901); 桂林创新平台与人才计划(20210102-3); 广东省重点领域研究发展计划(2020B1111110003)

A New Fatty Acid Glycoside Compound in Munronia Pinnata

Peiyuan Liua,b, Yulu Weib, Jingru Songb, Xiaojie Yanb, Fenglai Lub, Yueyuan Chengb, Xuerong Yangb(), Dianpeng Lib,c()   

  1. a School of Pharmacy, Guilin Medical University, Guilin, Guangxi 541004
    b Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy Sciences, Guilin, Guangxi 541006
    c Engineering Research Center of Innovative Traditional Chinese, Zhuang and Yao Materia Medica, Ministry of Education, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200
  • Received:2023-10-22 Revised:2023-11-28 Published:2023-12-15
  • Contact: E-mail: yxrxl@sina.cn; ldp@gxib.cn
  • Supported by:
    Natural Science Foundation of Guangxi(2020GXNSFBA297055); Guangxi Science and Technology Base and Talent Project (Guike AA21196009); National Key Research and Development Program(2022YFD1600302); National Natural Science Foundation of China(U20A2004); Basic Research Fund of Guangxi Academy of Sciences(CQZ-C-1901); Guilin Innovation Platform and Talent Plan(20210102-3); Key Area Research and Development Program of Guangdong Province(2020B1111110003)

The chemical constituents of the aerial parts of Munronia pinnata W. Theobald were investigated by using chro- matographic techniques. Ten compounds were isolated from the 95% ethanol extract of Munronia pinnata. Their structures were identified as munrofatty A (1), 2-[[6-O-((2E)-6R-hydroxy-2,6-dimethyl-2,7-octadienoyl)-β-D-glucopyranosyl]oxy]-2- methylpropanoic acid (2), kaempferol-3-O-(6-O-trans-p-coumaroyl)-β-D-glucopyranoside (3), castanoside A (4), kaempferol- 3-O-(6''-O-cis-pcoumaroyl)-β-D-glucopyranoside (5), aurantiamide acetate (6), blumenol A (7), grasshopper ketone (8), curcusinol (9) and loliolide (10) through detailed analyses of various technical means, including MS, IR, 1D- and 2D-NMR spectroscopic methods, quantum calculation methods and other technical means. Compound 1 is a new compound, while NMR data of compound 2 are presented for the first time. Compound 1 was evaluated for cytotoxicity against HCT116, A549, HepG2, MCF7 and MDAMB cells, and was non-toxic to the tested cells at a concentration of 160 μmol/L.

Key words: meliaceae, Munronia pinnata, munrofatty A, structural identification