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海洋来源真菌Cladosporium sp. MDCW-211次级代谢产物研究

王见见a, 郑圣䶮a, 张洁a, 高文鹏a, 孔凡栋a, 李培海b, 王聪a,*, 曹树更c,*   

  1. a广西民族大学化学化工学院 林产化学与工程国家民委重点实验室 广西林产化学与工程重点实验室 林木生物质低碳高质利用广西高校工程研究中心 广西民族大学 南宁 530006;
    b山东省斑马鱼人类疾病模型与药物筛选工程技术研究中心 齐鲁工业大学(山东省科学院)生物研究所 济南 250103;
    c夏威夷大学 药学院 夏威夷 96720
  • 收稿日期:2025-07-14 修回日期:2025-08-23
  • 基金资助:
    国家自然科学基金青年项目(82204276); 广西自然科学基金(No.2025GXNSFAA069557); 广西高等学校千名中青年骨干教师培育计划; 广西民族大学研究生教育创新计划项目(No.gxmzu-chxs2024225).

Study on Secondary Metabolites of Marine-derived Fungus Cladosporium sp. MDCW-211

Wang Jianjiana, Zheng Shengyana, Zhang Jiea, Gao Wenpenga, Kong Fandonga, Li Peihaib, Wang Conga,*, Cao Shugengc,*   

  1. aKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission; Guangxi Key Laboratory of Chemistry and Engineering of Forest Products; Engineering Research Center of Low-carbon and High-quality Utilization of Forest Biomass, University of Guangxi; School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, 530006, China;
    bEngineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China;
    cDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA
  • Received:2025-07-14 Revised:2025-08-23
  • Contact: *E-mail: wangcong123206@163.com; scao@hawaii.edu
  • Supported by:
    National Natural Science Foundation of China (No. 82204276), the Guangxi Natural Science Foundation (No.2025GXNSFAA069557), the Guangxi Scholarship Fund of Guangxi Education Department, and Innovation Project of Guangxi Minzu University Graduate Education (No.gxmzu-chxs2024225) ).

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Supporting Info.

1

A study was conducted on the biologically active secondary metabolites produced by the marine fungus Cladosporium sp. MDCW-211. Preparative High Performance Liquid Chromatography (HPLC) and other techniques were used to isolate and purify the compounds, the structures of the compounds were determined by HR-ESI-MS, NMR, X-ray and other methods, and the pro-angiogenic activity of the compounds was evaluated by zebrafish model. One new dihydroisocoumarin 1 (4'S-hydroxyasperentin) and three known dihydroisocoumarins 2-4 were obtained and identified. Compound 3 was tested at 20 and 40 μmol/L, and it demonstrated strong pro-angiogenic activity, which is reported here for the first time.

Key words: Marine fungus, Cladosporium sp. MDCW-211, dihydroisocoumarins, pro-angiogenic activity