Recent Advances on the Synthesis of Ten-Membered Nitrogen Heterocyclic Compounds

doi:10.6023/cjoc202508004

Abstract

Ten-membered nitrogen heterocyclic compounds, are not only the cores of many nitrogen-containing alkaloids but also the key intermediates for the construction of other natural products. Consequently, their efficient synthesis has garnered significant attention in the field of organic and medicinal chemistry. Over the past decade, since their special medium-sized rings and possessing good biological activities, the synthetic methodologies toward the preparation of ten-membered N-heterocyclic compounds have been greatly developed and have also become one of the hottest topics in the medium-sized ring synthetic fields. This review summarized the recent advances in the synthesis of ten-membered N-heterocyclic compounds in the last decade. It covered the innovative synthetic methodologies for these ten-membered nitrogen heterocyclic compounds and their applications in the total synthesis of natural products.

Key words: ten-membered N-heterocyclic compounds, medium-sized ring compounds, cyclization reaction, cycloaddition reaction, ring expansion reaction

Cite this article

Luo Yan, Liu Zhang-Wei, Hu Zhaolei, Bi Hong-Yan, Mo Dong-Liang. Recent Advances on the Synthesis of Ten-Membered Nitrogen Heterocyclic Compounds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202508004.

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