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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 05: 962 - 965

DOI: https://doi.org/10.6023/cjoc1109181

Notes

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid

  • Liu Weihua ,
  • Gao Shutao ,
  • Feng Cheng ,
  • Zang Xiaohuan ,
  • Zhou Xin ,
  • Ma Jingjun ,
  • Wang Chun
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  • College of Science, Agricultural University of Hebei, Baoding 071001

Received date: 2011-09-18

  Revised date: 2011-12-03

  Online published: 2012-01-04

Supported by

Project supported by the Natural Science Foundation of Hebei Province (No. B2011204051) and the Science and Engineering Foundation of Agricultural University of Hebei Province (No. LG201107).

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Abstract

A series of 3,4-dihydropyrimidin-2(1H)-ones were prepared through the Biginelli condensation reactions of aromatic aldehydes, keto ester and urea catalyzed by Brönsted acidic ionic liquid 3-methyl-1-(3-sulfopropyl)-imidazolium trifluoroacetate under solvent free conditions. The method is simple, solvent free, high yields and environmental friendly. The catalyst could be recycled and reused. The reactions were carried out in boiling water bath for 30～40 min. The yields of the products were between 81%～94%. All the products have been characterized by 1H NMR and IR spectra.

Key words： Brönsted acid-based ionic liquids; 3,4-dihydropyrimidin-2(1H)-one; synthesis

Cite this article

Liu Weihua , Gao Shutao , Feng Cheng , Zang Xiaohuan , Zhou Xin , Ma Jingjun , Wang Chun . Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Brönsted Acidic Ionic Liquid[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 962 -965 . DOI: 10.6023/cjoc1109181

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