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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 05: 943 - 948

DOI: https://doi.org/10.6023/cjoc1111291

Notes

Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides

  • Chen Hua ,
  • Gao Fang ,
  • Yin Qingmei ,
  • Li Chunxiao ,
  • Li Na ,
  • Meng Ming ,
  • Li Xiaoliu
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  • a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science,Hebei University, Baoding 071002;
    b Medical School, Hebei University, Baoding 071002

Received date: 2011-11-29

  Revised date: 2011-12-12

  Online published: 2012-01-06

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20972039, 21172051), the Natural Science Foundation of Hebei Province (No. B2011201169), the Natural Science Foundations of Education Department of Hebei Province (Nos. 2009309, ZH2011110, Y2011119), and the Program of Science and Technology of Hebei Province (No. 09276418D-13).

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Abstract

Novel thiazolidin-4-one-linked pseudotrisaccharides 3a and 3b were synthesized by the one-pot tandem Staudinger/ aza-Wittig/cyclization reaction at room temperature starting from a bis-azidosugar, a sugar aldehyde and mercaptoacetic acid. The debenzoylation of 3a and 3b afforded the corresponding compounds 4a and 4b, respectively. The preliminary biological evaluation of compounds 4a and 4b showed that compounds 4a and 4b had significant effects on T-cell proliferation, and hold potential as immunostimulating agents.

Key words： thiazolidin-4-one; pseudotrisaccharides; immunostimulating agent

Cite this article

Chen Hua , Gao Fang , Yin Qingmei , Li Chunxiao , Li Na , Meng Ming , Li Xiaoliu . Synthesis and Proliferative Effects on T Lymphocytes of Novel Thiazolidin-4-one Linked Pseudotrisaccharides[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 943 -948 . DOI: 10.6023/cjoc1111291

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