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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 05: 957 - 961

DOI: https://doi.org/10.6023/cjoc1111162

Notes

Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles

  • Weng Jianquan ,
  • Huang Hua ,
  • Tan Chengxia ,
  • Liu Xinghai ,
  • Chu Weisheng ,
  • Chen Jie
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  • a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032;
    b Bioassay Department, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023

Received date: 2011-10-16

  Revised date: 2011-12-13

  Online published: 2012-01-06

Supported by

Project supported by the National Natural Science Foundation of China (No. 30900959).

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Abstract

In order to find new benzothiazole lead compounds, eighteen new substitued-3-aryl-1,2,4-triazolo[3,4-b]-benzothiazoles were synthesized by reacting substituted-2-hydrazinobenzothiazole with various substituted benzoic acids in POCl3 under reflux condition. The structures of the title compounds were characterized by 1H NMR, EIMS techniques and elemental analysis. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Rhizoctonia solani, Ascochyta citrullina, Fusarium oxysporum f.sp. cubense and Colletotrichum nicotianae. Unexpectedly, some of them possessed certain promotion activity against Botrytis cinerea.

Key words： 1,2,4-triazolo[3,4-b]benzothiazole; synthesis; antifungal activity

Cite this article

Weng Jianquan , Huang Hua , Tan Chengxia , Liu Xinghai , Chu Weisheng , Chen Jie . Synthesis and Antifungal Activity of Novel Substituted- 3-aryl-1,2,4-triazolo[3,4-b]benzothiazoles[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 957 -961 . DOI: 10.6023/cjoc1111162

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