Articles

Synthesis, DNA Binding Properties and Bioactivity of Naphthalimide Poly(ethylene imine) Conjugates

  • Wang Kerang ,
  • An Hongwei ,
  • Wang Yueqing ,
  • Yan Xinhao ,
  • Li Rui ,
  • Chen Hua ,
  • Zhang Pingzhu ,
  • Li Jinmei ,
  • Li Xiaoliu ,
  • Zhang Jinchao
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  • a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b Department of Pathology, The First Central Hospital of Baoding, Baoding 071000;
    c Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002

Received date: 2011-09-22

  Revised date: 2011-12-20

  Online published: 2012-04-24

Supported by

Project supported by the 973 Program (No. 2010CB534913), the National Natural Science Foundation of China (Nos. 21002020, 21172051), the Natural Science Foundation of Hebei Province (No. B2011201052), the Foundation of Hebei Education Department (No. 2010106) and the Foundation of Baoding Science and Technology Department (No. 11ZF123).

Abstract

A series of novel low molecular weight poly(ethylene imine) (diethylenetriamine, triethylenetetraamine and tetraethylenepentamine) modified naphthalimide derivatives at 4 position as the DNA binding agents were designed and synthesized. Their DNA binding properties were investigated by UV-Vis, fluorescence and circular dischroism (CD) spectroscopies and thermal denaturation experiment. Furthermore, the anticancer activity was evaluated against different tumor cell lines (human hepatocellular carcinoma Bel-7402, cells, human promyelocytic leukemia HL-60 cells, human lung cancer A549 cell, human cervical carcinoma Hela cell). Compound NI1 exhibited potent anticancer activity against A549 cell line with IC50 value of 3.16 μmol/L, which was better than the positive control drug (cisplatin).

Cite this article

Wang Kerang , An Hongwei , Wang Yueqing , Yan Xinhao , Li Rui , Chen Hua , Zhang Pingzhu , Li Jinmei , Li Xiaoliu , Zhang Jinchao . Synthesis, DNA Binding Properties and Bioactivity of Naphthalimide Poly(ethylene imine) Conjugates[J]. Chinese Journal of Organic Chemistry, 2012 , 32(04) : 696 -702 . DOI: 10.6023/cjoc1112052

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