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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 06: 1141 - 1145

DOI: https://doi.org/10.6023/cjoc1109222

Notes

A New Synthesis of 2-Amino-4,5-substituted Pyrimidine Derivatives

  • Deng Lanqing ,
  • Xu Zhonghai ,
  • Shang Yunfeng ,
  • Dai Wenjing ,
  • Hu Huimin ,
  • Deng Suiping ,
  • Ouyang Jianming
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  • a Key Laboratory of Yueyang Chinese Herbal Utilization, Yueyang Vocational Technical College, Yueyang 414000;
    b Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632

Received date: 2011-09-22

  Revised date: 2011-12-20

  Online published: 2012-02-14

Supported by

Project supported by the National Natural Science Foundation of China (No. 30672103) and the Fundation of Hunan Educational Committee (No. 10C0336).

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Abstract

In this paper, a novel synthetic method for 2-amino-4,5-substituted pyrimidine derivatives was reported, which began from cheap and simple four aromatic aldehydes and three aliphatic aldehydes. 12 compounds of 2-amino-4,5-substituted pyrimidine derivatives were synthesized by four steps with yields of 40%～70%. The structures of terminational compounds were determined by 1H NMR, 13C NMR and LC-MS techniques.

Key words： 2-amino-pyrimidine; aromatic aldehyde; aliphatic aldehyde; synthesis

Cite this article

Deng Lanqing , Xu Zhonghai , Shang Yunfeng , Dai Wenjing , Hu Huimin , Deng Suiping , Ouyang Jianming . A New Synthesis of 2-Amino-4,5-substituted Pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(06) : 1141 -1145 . DOI: 10.6023/cjoc1109222

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