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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 01: 169 - 173

DOI: https://doi.org/10.6023/cjoc1107042

Notes

Synthesis and Antitumor Activities of the Diacid Solanesyl 5-Fluorouracil Esters Derivatives

  • XIAO Ke-Yi ,
  • DAI Ya ,
  • SHI Wan-Qi ,
  • LI Jian-Zhong ,
  • LI Ying ,
  • YIN Shu-Fan
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  • a School of Chemistry, Sichuan University, Chengdu 610064;
    b Harmful Components and Tar Reduction in Cigarette Sichuan Key Laboratory, Technical Research Center Chuanyu Branch of China Tobacco Corporation, Chengdu 610000;
    c Sichuan Guokang Pharmaceutical Company Limited, Chengdu 610041

Received date: 2011-07-04

  Revised date: 2011-09-05

  Online published: 2011-09-20

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Abstract

Twelve diacid solanesyl tegafur esters were synthesized by the reaction of solanesol with four acid anhydrides and N-alkoxy-tegafur. Their chemical structures were confirmed by IR, 1H NMR and MS techniques. The preliminary bioassay results show that the target compounds possess antitumor activities to some extent.

Key words： solanesol; tegafur; synthesis; antitumor activity

Cite this article

XIAO Ke-Yi , DAI Ya , SHI Wan-Qi , LI Jian-Zhong , LI Ying , YIN Shu-Fan . Synthesis and Antitumor Activities of the Diacid Solanesyl 5-Fluorouracil Esters Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(01) : 169 -173 . DOI: 10.6023/cjoc1107042

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