A series of novel chalcone derivatives bearing the 2,4-thiazolidinedione-3-acetic acid moieties (8a～8p) were synthesized, and evaluated for their anti-bacterial activity. The results demonstrated that some compounds presented good antimicrobial activities against four multidrug-resistant clinical isolates, among which compounds 8g, 8i, 8l and 8m with minimum inhibitory concentration (MIC) value of 4 μg/mL showed as active as the standard drug, norfloxacin, against methicillin- resistant S. aureus. None of the compounds exhibited obvious activity against the Gram-negative bacteria E. coli 1356 at 64 μg/mL.
MENG Fan-Ling
,
ZHENG Chang-Ji
,
LI Yin-Jing
,
SUN Liang-Peng
,
LIU Xue-Kun
,
ZHANG Tian-Yi
,
PU Hu-Ri
. Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety[J]. Chinese Journal of Organic Chemistry, 2012
, 32(01)
: 183
-188
.
DOI: 10.6023/cjoc1107182
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