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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 01: 1 - 12

DOI: https://doi.org/10.6023/cjoc1110141

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Progresses in Total Synthesis of Englerin A and Biological Evaluations of Its Analogues

  • LU Yun-Yu ,
  • YAO He-Quan ,
  • SUN Bing-Feng
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  • a School of Pharmacy, China Pharmaceutical University, Nanjing 210009;
    b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received date: 2011-10-14

  Revised date: 2011-11-17

  Online published: 2011-11-17

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20902101, 21172246) and the National Basic Research Program of China (973 Program, No. 2010CB833206).

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Abstract

Englerin A is an oxo-bridged guaiane-type sesquiterpenoid isolated from Phyllanthus engleri, and displays potent and highly selective inhibitory activities against renal cancer cell lines. In this review, the recent progresses since its disclosure in the total synthesis of englerin A and biological evaluations of its analogues are summarized, with an emphasis on the strategies of the synthetic routes, particularly in regards to the construction of oxatricyclic ring system.

Key words： englerin A; total synthesis; biological evaluation; progress

Cite this article

LU Yun-Yu , YAO He-Quan , SUN Bing-Feng . Progresses in Total Synthesis of Englerin A and Biological Evaluations of Its Analogues[J]. Chinese Journal of Organic Chemistry, 2012 , 32(01) : 1 -12 . DOI: 10.6023/cjoc1110141

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