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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 02: 338 - 343

DOI: https://doi.org/10.6023/cjoc1104192

Articles

A Stereoselective Synthesis of the C(13)-C(23) Fragment of Iriomoteolide-1b

  • YANG Zhen ,
  • JING Peng ,
  • SHE Xue-Gong
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  • State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000

Received date: 2011-04-19

  Revised date: 2011-09-08

  Online published: 2012-03-09

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20872054, 20732002).

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Abstract

A stereoselective synthesis of C(13)-C(23) subunit of iriomoteolide-1b has been achieved in 13% yield over 13 steps from the known diol, exploiting the asymmetric aldol reaction and the Julia-Kocienski olefination as the key steps. In order to reduce the cost of the synthesis we adopted usual reactions and used inexpensive reagents through the synthesis strategy.

Key words： iriomoteolide-1b; stereoselective synthesis; asymmetric aldol reaction; Julia-Kocienski olefination

Cite this article

YANG Zhen , JING Peng , SHE Xue-Gong . A Stereoselective Synthesis of the C(13)-C(23) Fragment of Iriomoteolide-1b[J]. Chinese Journal of Organic Chemistry, 2012 , 32(02) : 338 -343 . DOI: 10.6023/cjoc1104192

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