Four methods were tested to synthesize nicotinamide adenine dinucleotide (NAD) analogs, and 5 NAD analogs were prepared. Assays of these NAD analogs indicated that malic enzyme and alcohol dehydrogenase had about 13%～30% enzymatic activity in the presence of analog 3b or 3d, whereas significantly lower activities were observed in the presence of analog 3a, 3c or 3e.
HOU Shu-Hua
,
LIU Wu-Jun
,
ZHAO Zong-Bao
. Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities[J]. Chinese Journal of Organic Chemistry, 2012
, 32(02)
: 349
-353
.
DOI: 10.6023/cjoc1106032
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