Notes

A Facile and Efficient Synthesis of 3-Carbonitrile Pyridin-2(1H)-one Derivatives under Solvent-Free Conditions

  • RONG Liang-Ce ,
  • LIU Li-Hua ,
  • YIN Shan ,
  • XIA Sheng ,
  • WEI Xian-Yong ,
  • ZONG Zhi-Min
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  • a School of Chemical Engineering and Technology, China University of Mining and Technology,Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Xuzhou Normal University Xuzhou 221116

Received date: 2011-04-14

  Revised date: 2011-07-21

  Online published: 2012-03-09

Supported by

Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), and the Research Platform Foundation of Xuzhou Normal University (No. 10XLS02).

Abstract

An efficient and convenient method for the preparation of 3-carbonitrile pyridin-2(1H)-one derivative by the one-pot reaction of aromatic aldehydes, acetones and 2-cyanoacetamide in the presence of sodium hydroxide under solvent- free condition was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work-up, and environmentally friendly procedure.

Cite this article

RONG Liang-Ce , LIU Li-Hua , YIN Shan , XIA Sheng , WEI Xian-Yong , ZONG Zhi-Min . A Facile and Efficient Synthesis of 3-Carbonitrile Pyridin-2(1H)-one Derivatives under Solvent-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2012 , 32(02) : 400 -403 . DOI: 10.6023/cjoc1104143

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