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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 02: 420 - 430

DOI: https://doi.org/10.6023/cjoc1108212

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Progress in the Synthesis of Indole Alkaloid Uleine and Its Derivatives

  • WANG Xue-Jun ,
  • LIU Jian-Li ,
  • HUANG Xin-Wei ,
  • WANG Cui-Ling
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  • a Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, Xi'an 710069;
    b Department of Chemistry, Gansu College of Traditional Chinese Medicine, Lanzhou 730000

Received date: 2011-08-21

  Revised date: 2011-10-09

  Online published: 2012-03-09

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20872118, 30070905), the Doctoral Fund of Ministry of Education of China (No. 20070697012), the Major Science and Technology Projects of Shaanxi Province (No. 2008ZDKG-67) and the Foundation of State Key Laboratory of Shaanxi Province (Nos. 2010JS097, 08jk477).

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Abstract

Uleine and its derivatives belong to the monoterpenoid indole alkaloids based on their structures. The characteristic of their structures is only one carbon atom which separates the indole nucleus and the basic nitrogen atom, as opposed to the normal two-carbon bridge of tryptamine and most monoterpenoid indole alkaloids. Their natural contents are extremely low, and their synthetic work has attracted generations of chemists. The synthetic methods of uleine and its derivatives are reviewed according to the types of structure building methodology. The indole and pyridine derivatives were used as the starting material in most tetracyclic synthesis. Several simple and convenient routes are succeeded.

Key words： uleine; derivative; synthesis; review

Cite this article

WANG Xue-Jun , LIU Jian-Li , HUANG Xin-Wei , WANG Cui-Ling . Progress in the Synthesis of Indole Alkaloid Uleine and Its Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(02) : 420 -430 . DOI: 10.6023/cjoc1108212

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