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Chinese Journal of Organic Chemistry >

2012 >Issue 03: 593 - 596

DOI: https://doi.org/10.6023/cjoc1101201

Notes

Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides

  • Gong Jingxu ,
  • Sheng Li ,
  • Yao Ligong ,
  • Li Jia ,
  • Zhou Yubo ,
  • Guo Yuewei
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  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received date: 2011-01-20

  Revised date: 2011-11-08

  Online published: 2012-03-24

Supported by

Project supported by the National S & T Major Project (Nos. 2009ZX09301-001, 2009ZX09103-060), the Natural Science Foundation of China (Nos. 81072572, 21072204, 21021063), the National Marine “863” Project (No. 2011AA09070102), the Basic Research Project of Shanghai Science and Technology Commission (Nos. 09ZR1438000, 10540702900), and the Key Program of the Chinese Academy of Sciences (Nos. KSCX2-EW-R-15, KSCX2-YW-R-18).

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Abstract

A series of alkyl heterocyclyl disulfides were prepared by reaction of the heterocyclyl thiol with Bunte salts. All the synthesized compounds showed interesting inhibit activities toward human colon carcinoma cells (HCT-116) in vitro. The IC50 values of the tested compounds ranged from 4.8 μg·mL-1 to 17.7 μg·mL-1.

Key words： disulfides; synthesis; anti-tumor activity

Cite this article

Gong Jingxu , Sheng Li , Yao Ligong , Li Jia , Zhou Yubo , Guo Yuewei . Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides[J]. Chinese Journal of Organic Chemistry, 2012 , (03) : 593 -596 . DOI: 10.6023/cjoc1101201

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