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Chinese Journal of Organic Chemistry >

2012 >Issue 03: 601 - 607

DOI: https://doi.org/10.6023/cjoc1106152

Notes

Hydroxymethylation and Aminomethylation of 2-Aminothiazol Derivatives at 5 Position

  • Wang Feng ,
  • Li Wenhong ,
  • Li Dong ,
  • Fan Zheng ,
  • Li Zhen
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  • a School of Chemical Engineering, Northwest University, Xi'an 710069;
    b Shaanxi Research Design Institute of Petroleum and Chemical Industry, Xi'an 710054

Received date: 2011-06-15

  Revised date: 2011-10-20

  Online published: 2012-03-24

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Abstract

Hydroxymethylation of 2-aminothiazol derivatives at 5 position irritated by microwave was reported. The reaction results were compared by the method of microwave, sealed tube and reduction from ester. A series of novel hydroxymethyl derivatives were obtained. Through the experiments, sealed tube condition demanded high thermal stability of the substrate, and the reaction yield was low with messy reaction solution and long reaction time. The yield of reduction from ester is poor with longer synthetic route. The hydroxymethylation under microwave irradiation gave high yields with short reaction times. 2-Cyanoacetate sodium salt was prepared from NaH, and the yield was improved. Novel derivatives of aminomethylation on 5 position are obtained after cyclization and reduction.

Key words： 2-aminothiazole; microwave reaction; thiazole

Cite this article

Wang Feng , Li Wenhong , Li Dong , Fan Zheng , Li Zhen . Hydroxymethylation and Aminomethylation of 2-Aminothiazol Derivatives at 5 Position[J]. Chinese Journal of Organic Chemistry, 2012 , (03) : 601 -607 . DOI: 10.6023/cjoc1106152

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