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Chinese Journal of Organic Chemistry >

2012 >Issue 03: 612 - 615

DOI: https://doi.org/10.6023/cjoc1108072

Notes

A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

  • Liu Lihua ,
  • Yin Shan ,
  • Xia Sheng ,
  • Cai Peijun ,
  • Rong Liangce
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  • a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116

Received date: 2011-08-07

  Revised date: 2011-10-22

  Online published: 2012-03-24

Supported by

Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Research Platform Foundation of Xuzhou Normal University (No. 10XLS02).

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Abstract

An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes, ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K2CO3 as catalyst under solvent-free conditions at about 70 ℃ is reported. This protocol has the advantages of shorter time, mild conditions, easy work-up and environmental friendliness. The products were identified by IR, 1H NMR and HRMS techniques, and that of 4e was additionally confirmed by X-ray diffraction analysis.

Key words： 6-oxo-pyrimidine; heterocyclic compound; solvent-free reaction

Cite this article

Liu Lihua , Yin Shan , Xia Sheng , Cai Peijun , Rong Liangce . A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2012 , (03) : 612 -615 . DOI: 10.6023/cjoc1108072

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