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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 06: 1072 - 1076

DOI: https://doi.org/10.6023/cjoc1202052

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Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides with 6-Chloropurines

  • Wang Dong-Chao ,
  • Niu Hong-Ying ,
  • Guo Hai-Ming ,
  • Wei Xue-Jiao ,
  • Ding Rui-Fang ,
  • Gui-Rong Qu
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  • a College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007;
    b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003

Received date: 2012-02-05

  Revised date: 2012-02-24

  Online published: 2012-03-31

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20772024, 21072047, 21172059), the Program for New Century Excellent Talents in University of Ministry of Education (No. NCET-09-0122), and the Excellent Youth Foundation of Henan Scientific Committee (No. 114100510012).

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Abstract

An efficient method for the synthesis of 6-acyclic secondary alkyl purines was developed via nickel-catalyzed Negishi cross-cuplings of 6-chloropurines with acyclic secondary alkylzinc halides in the presence of phenanthroline at room temperature. The process gave good to excellent isolated yields under very mild conditions.

Key words： Purine; Negishi Cross-Coupling; Organozinc Halides

Cite this article

Wang Dong-Chao , Niu Hong-Ying , Guo Hai-Ming , Wei Xue-Jiao , Ding Rui-Fang , Gui-Rong Qu . Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides with 6-Chloropurines[J]. Chinese Journal of Organic Chemistry, 2012 , 32(06) : 1072 -1076 . DOI: 10.6023/cjoc1202052

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