Notes

One Pot Synthesis of Novel 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol Derivatives

  • Liu Hanwen ,
  • Pei Wenchou ,
  • Tang Zilong
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  • Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan 411201

Received date: 2011-10-13

  Revised date: 2012-02-22

  Online published: 2012-03-31

Supported by

Project supported by the National Natural Science Foundation of China (No. 20971041) and the Natural Science Foundation of Hunan Province (No. 11JJ3016).

Abstract

A new class of 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol compounds were synthesized via the nucleophilic addition reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-hydroxybenzaldehyde, dehydration and reduction of unsaturated double bond in one-pot. This procedure has the advantages of short reaction time and simple post treatment. The structures of the products were characterized thoroughly by elementary analysis, NMR, IR and MS techniques.

Cite this article

Liu Hanwen , Pei Wenchou , Tang Zilong . One Pot Synthesis of Novel 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(07) : 1332 -1335 . DOI: 10.6023/cjoc1110131

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