Notes

Synthesis and Fungicidal Activity of 6-(Substituted benzylthio)-3- (3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

  • Du Haitang ,
  • Sang Weijun ,
  • Wang Hui
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  • a Department of Chemistry, Guiyang College, Guiyang 550005;
    b College of Agriculture, Guizhou University, Guiyang 550025

Received date: 2011-12-02

  Revised date: 2012-03-06

  Online published: 2012-04-11

Supported by

Project supported by the Science and Technology Foundation of Guizhou Province (No. [2010]2278), the Natural Science Foundation of Guizhou Provincial Education Department (No. [2008]050) and the Talent Innovation and Entrepreneurship of Guiyang City (No. [2010]012).

Abstract

3-(3,4,5-Trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole-6-thiol (2) has been obtained by the cyclization of 4-amino-5-(3,4,5-trimethoxybenzyl)-3-sulfydryl-1,2,4-triazole (1) with carbon disulfide in the presence of potassium hydroxide. Then the target compounds 3a3i were prepared from 3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b]-[1,3,4]- thiadiazole-6-thiol with various substituted benzyl chlorides. Their structures were confirmed by IR, 1H NMR, MS techniques and elemental analysis, and fungicidal activity was studied as well. Preliminary bioassay test indicated that some of the compounds had obvious fungicidal activity.

Cite this article

Du Haitang , Sang Weijun , Wang Hui . Synthesis and Fungicidal Activity of 6-(Substituted benzylthio)-3- (3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole[J]. Chinese Journal of Organic Chemistry, 2012 , 32(08) : 1539 -1542 . DOI: 10.6023/cjoc1112021

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