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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 04: 641 - 650

DOI: https://doi.org/10.6023/cjoc1107172

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Progress in the Synthesis of Optically Pure Ethyl 2-Hydroxy-4-phenylbutyrate

  • Zhu L黤eng ,
  • Chen Houhe ,
  • Meng Qinghua ,
  • Xie Xiaomin ,
  • Li Yuegang ,
  • Zhang Zhaoguo
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  • a School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094;
    b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240;
    c Sinochem International (Suzhou) New Material R&D Co., Ltd, Suzhou 215433

Received date: 2011-07-17

  Revised date: 2011-10-27

  Online published: 2012-04-24

Supported by

Project supported by the National Natural Science Foundation of China (No. 20872090).

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Abstract

(R)-2-Hydroxy-4-phenylbutyrate is a key intermediate for the synthesis of angiotensin-converting enzyme inhibitors (ACEI). The review will cover its synthetic methods, and mainly focus on the recent progress in efficient synthesis.

Key words： ethyl (R)-2-hydroxy-4-phenylbutyrate; angiotensin-converting enzyme inhibitor; asymmetric hydrogenation; enzyme; ruthenium

Cite this article

Zhu L黤eng , Chen Houhe , Meng Qinghua , Xie Xiaomin , Li Yuegang , Zhang Zhaoguo . Progress in the Synthesis of Optically Pure Ethyl 2-Hydroxy-4-phenylbutyrate[J]. Chinese Journal of Organic Chemistry, 2012 , 32(04) : 641 -650 . DOI: 10.6023/cjoc1107172

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