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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 08: 1459 - 1467

DOI: https://doi.org/10.6023/cjoc1201101

Articles

Microwave-Assisted Synthesis of 2-Substituted-4,5-diarylimidazoles from Benzoin Carboxylate Derivatives under Solvent-Free Conditions

  • Li Baozhi ,
  • Gu Qiang ,
  • Zhao Tianqi ,
  • He Yuanhui ,
  • Tong Yanan ,
  • Zhang Yumin
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  • College of Chemistry, Jilin University, Changchun 130012

Received date: 2012-01-10

  Revised date: 2012-03-10

  Online published: 2012-04-24

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Abstract

Benzoin carboxylate derivatives were synthesized with the aromatic aldehydes as raw material in the presence of the catalyst VB1. And then, benzoin carboxylate derivatives reacted with different acylating reagents under mild reaction conditions, and benzoin carboxylates were obtained. Further, 2-substituted-4,5-di(aryl)imidazoles were produced from benzoin carboxylates in the presence of solid supports Al2O3 under solvent-free and microware assisted condition, and seven of them have not been reported. The reaction possessed many advantages such as mild reaction conditions, short reaction time, and no organic solvents consumed. Therefore, it is a facile and efficient synthetic method. Moreover, the synthesized compounds were characterized by 1H NMR, 13C NMR, IR, HRMS techniques.

Key words： 2-substituted-4,5-di(aryl)imidazoles; benzoin carboxylates; microwave-assisted synthesis; solid-support; solvent-free; esterification

Cite this article

Li Baozhi , Gu Qiang , Zhao Tianqi , He Yuanhui , Tong Yanan , Zhang Yumin . Microwave-Assisted Synthesis of 2-Substituted-4,5-diarylimidazoles from Benzoin Carboxylate Derivatives under Solvent-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2012 , 32(08) : 1459 -1467 . DOI: 10.6023/cjoc1201101

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