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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 08: 1533 - 1538

DOI: https://doi.org/10.6023/cjoc1202271

Notes

Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

  • Zhang Jitan ,
  • Zhang Jinhua ,
  • Fang Kuang ,
  • Shu Guanying ,
  • Xie Meihua
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  • College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000

Received date: 2012-02-27

  Revised date: 2012-04-11

  Online published: 2012-04-24

Supported by

Project supported by the National Natural Science Foundation of China (No. 20772001).

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Abstract

FeCl3?6H2O-catalyzed intramolecular Friedel-Crafts cyclization of multisubstituted allylic alcohols proceeded smoothly and a series of multisubstituted indenes were synthesized in moderate to high yields. The reaction has the advantages of simple manipulation and mild reaction conditions. The products were characterized by IR, 1H NMR, 13C NMR, HR MS and X-ray diffraction analysis.

Key words： allylic alcohol; FeCl3?6H2O; Friedel-Crafts cyclization; indene

Cite this article

Zhang Jitan , Zhang Jinhua , Fang Kuang , Shu Guanying , Xie Meihua . Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols[J]. Chinese Journal of Organic Chemistry, 2012 , 32(08) : 1533 -1538 . DOI: 10.6023/cjoc1202271

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